What antidepressants can I take with Contrave (naltrexone/bupropion)?

It is important that your medical provider review any antidepressants you are currently taking before prescribing Contrave®. Contrave contains the antidepressant Wellbutrin® (bupropion), so if you are already taking Wellbutrin, it is not recommended to add Contrave. Depending on your medical history and medications you are taking, the combination of Contrave with other antidepressants may increase the risk for seizures. Certain antidepressants known as monoamine oxidase inhibitors (MAOis) (e.g. selegiline, isocarboxazid, phenelzine, and tranylcypromine) are contraindicated in combination with Contrave. If you have recently stopped taking a MAOi, you must wait at least 2 weeks before starting Contrave. Lastly, if you are currently taking Contrave, make sure to discuss this with your medical provider before taking any new antidepressant medication.

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Form Health is a virtual obesity medicine clinic founded in 2019 that provides science-based obesity care to help patients achieve their weight loss and health goals. Patients have the opportunity to achieve sustainable weight loss by working closely with an American Board of Obesity Medicine physician and a Registered Dietitian who is a Board Certified Specialist in Obesity and Weight Management. Each Care Team develops a personalized treatment plan based on a comprehensive review of their medical history that includes behavioral support, nutrition, physical activity, and medication, if appropriate.

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Contrave® is a registered trademark of Currax Pharmaceuticals, LLC.