How much weight can you lose on Zepbound (tirzepatide)?

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The amount of weight a person can lose when taking Zepbound™ depends on a variety of factors. Keep in mind that Zepbound is FDA-approved for individuals with a body mass index (BMI) of 30 or higher or 27 or higher with a weight related medical condition such as diabetes, high blood pressure, high cholesterol, etc. and is to be used in combination with a low calorie nutrition plan and increased physical activity. In a clinical trial, participants taking the highest dose of Zepbound (15 mg) lost an average of ~22% of their starting body weight on the medication, which was the equivalent of approximately 50 lbs. That being said, individual responses to the medication will vary. Typically, when starting a weight loss medication we look for at least 5% weight loss after 3 months on the medication. If a person has not reached that benchmark, it’s less likely that this is an effective medication and alternative treatment options should be considered. If you are taking Zepbound and struggling to lose weight, please discuss this with your medical provider.

Zepbound™ and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

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Lauren Lemieux, MD

Lauren Lemieux, MD

FACP, ABOM diplomate

Dr. Lauren Lemieux completed her Internal Medicine residency and fellowship in Clinical Nutrition at UCLA. She is board certified in Internal Medicine and diplomate of the American Board of Obesity Medicine, and as a Physician Nutrition Specialist. She is also a fellow of the American College of Physicians. Dr. Lemieux is passionate about helping her patients reach their health goals using personalized nutrition, lifestyle and weight management strategies.