How Long Does It Take Zepbound (Tirzepatide) to Start Working?

Zepbound™ starts to take effect in an individual as soon as it is administered, but how soon an individual notices its effects will vary. The dose of the medication is gradually increased each month so that the body can adjust to the medication while reducing the risk of more severe side effects that can occur if a higher dose is taken too soon. Some patients notice an immediate reduction in appetite while others require higher doses to have an effect. The rate at which someone loses weight depends on numerous factors including caloric intake, age, activity level, and other medications a person may be taking. Therefore, there is not a standard expected rate of weight loss. A recent study looked at patients who lost at least 5% of their body weight after 3 months with a combination of Zepbound and intensive lifestyle changes. When these individuals took Zepbound for up to a year and a half, they lost an average of 26.6% of their body weight.  It is important to discuss whether this medication is working for you with your medical provider. Typically if a person has been taking Zepbound for at least 3 months and has not lost at least 5% of the starting weight it is recommended to stop the medication.

Learn more about how FORM can prescribe Zepbound  for weight loss.

Zepbound™ and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

Am I a candidate?

Take our free 3 minute quiz to see if you qualify for FORM.

Lauren Lemieux, MD

Lauren Lemieux, MD

FACP, ABOM diplomate

Dr. Lauren Lemieux completed her Internal Medicine residency and fellowship in Clinical Nutrition at UCLA. She is board certified in Internal Medicine and diplomate of the American Board of Obesity Medicine, and as a Physician Nutrition Specialist. She is also a fellow of the American College of Physicians. Dr. Lemieux is passionate about helping her patients reach their health goals using personalized nutrition, lifestyle and weight management strategies.

Have questions?

Schedule a call with a FORM Care Advisor, and get answers to all your questions before signing up.