How does Contrave (naltrexone-bupropion) make you feel?

Contrave® is a combination of an opiate receptor blocker (naltrexone) and an antidepressant (bupropion), and it is thought to help people lose weight by acting on areas of the brain to decrease appetite and food cravings.  As Contrave includes the antidepressant bupropion, some people may note improvement in mood(1) and energy levels while others may notice it makes them more anxious or irritable. You may feel that you do not have the same desire to turn to your favorite food when under stress or upset when taking Contrave. If you have a history of a mood disorder like depression, anxiety or bipolar disorder, you should discuss this with your doctor before starting Contrave.  

  1. Contrave is not FDA-approved for treatment of depression.

Learn more about who qualifies for Contrave and how FORM doctors prescribe Contrave to help patients achieve their weight loss goals.

Contrave® is a registered trademark of Currax Pharmaceuticals LLC

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Lauren Lemieux, MD

Lauren Lemieux, MD

FACP, ABOM diplomate

Dr. Lauren Lemieux completed her Internal Medicine residency and fellowship in Clinical Nutrition at UCLA. She is board certified in Internal Medicine and diplomate of the American Board of Obesity Medicine, and as a Physician Nutrition Specialist. She is also a fellow of the American College of Physicians. Dr. Lemieux is passionate about helping her patients reach their health goals using personalized nutrition, lifestyle and weight management strategies.