How Does Mounjaro (Tirzepatide) Work for Weight Loss?

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Mounjaro™ is an injectable medication that is a combination GIP/GLP-1 receptor agonist.  It mimics two hormones our body naturally makes- GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1). GLP-1 acts on the pancreas to stimulate the release of insulin which lowers blood sugar and acts on the brain to decrease appetite and cravings.  The addition of a GIP agonist to a GLP-1 agonist has been found to promote additional weight loss. Overall, Mounjaro can decrease appetite and in combination with a low-calorie nutrition plan and increased physical activity can lead to weight loss.  However, it is important to note that currently Mounjaro is only FDA-approved for the treatment of type 2 diabetes and not specifically for weight loss. Zepbound™, which contains the same active ingredient (tirzepatide) as Mounjaro, has been recently approved for the treatment of weight loss. Which medication you are prescribed depends on a variety of factors such as your insurance coverage, any medical conditions you may have, and which medication your healthcare provider determines to be appropriate for you. 

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Mounjaro™ and Zepbound™ and their delivery device bases are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.