Does Ozempic® (Semaglutide) Cause Heartburn?

Though heartburn is not listed as a common side effect of Ozempic® on the drug manufacturer’s website, new or worsening heartburn can be seen with initiation of GLP-1 receptor agonist medications like Ozempic. These medications slow down digestion, which can contribute to acid reflux, in addition to other gastrointestinal symptoms such as nausea, vomiting, and constipation. In those participating in trials for Wegovy®, a medication similar to Ozempic that contains the key active ingredient semaglutide, 5% of those taking the medication reported heartburn, compared to only 3% taking a placebo. Non-pharmaceutical tips to manage heartburn associated with Ozempic include avoiding foods and beverages that trigger reflux (most commonly spicy foods, tomato-based products, chocolate, onions, garlic, citrus, and peppermint, in addition to alcohol, caffeinated beverages, and carbonated beverages), eating smaller portions, not eating close to bedtime, and quitting tobacco use. 

Wegovy® and Ozempic® are a registered trademarks of Novo Nordisk A/S.

Am I a candidate?

Take our free 3 minute quiz to see if you qualify for FORM.

Nathaniel Pedley, MD

Nathaniel Pedley, MD

ABOM Diplomate

Dr. Nathaniel Pedley is an internist and obesity medicine specialist who is passionate about supporting patients in achieving their health goals. He attended Amherst College in Massachusetts for undergrad, and completed a post-baccalaureate in pre-medical studies at Columbia University. He continued at Columbia University for medical school and went on to complete his residency in internal medicine at UCLA where he served as a Project Lead for the UCLA Department of Medicine Quality Team and a peer mentor to junior residents.