How long does Mounjaro (tirzepatide) stay in your system?

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Mounjaro® stays in your system for about 30 days once you stop taking the medication. This is based on the half-life of the medication which is the time it takes for 50% of the drug to be removed. The half life of Mounjaro is 5 days, though keep in mind that this is an estimate and the time it takes for Mounjaro to leave your system may vary from person to person. If you miss taking your Mounjaro, administer the missed dose as soon as possible within 4 days. If it has been more than 4 days, skip the missed dose and administer the next dose on your usual injection day. If it is has been more than 2 weeks since your last dose, please notify your prescribing medical provider.  

Learn more about Mounjaro prescribing information, including who qualifies for Mounjaro.

Mounjaro® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

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Lauren Lemieux, MD

Lauren Lemieux, MD

FACP, ABOM diplomate

Dr. Lauren Lemieux completed her Internal Medicine residency and fellowship in Clinical Nutrition at UCLA. She is board certified in Internal Medicine and diplomate of the American Board of Obesity Medicine, and as a Physician Nutrition Specialist. She is also a fellow of the American College of Physicians. Dr. Lemieux is passionate about helping her patients reach their health goals using personalized nutrition, lifestyle and weight management strategies.